The Choice of Administration Options
Talk to your patients about the most convenient option for them
BENLYSTA Autoinjector for SC use
200 mg/mL single-dose prefilled Autoinjector
Once weekly dosing with at-home convenience
BENLYSTA Autoinjector dosing for SLE

BENLYSTA Autoinjector dosing for active lupus nephritis

* The 400-mg dose requires administration of 2 autoinjectors (2 x 200 mg). The dose is given via subcutaneous injection in the abdomen or thigh. When the 400-mg dose is administered at the same site, it is recommended that the 2 individual 200-mg injections be administered at least 5 cm (approximately 2 inches) apart.
Autoinjector
Transitioning from IV therapy to SC administration

Patients with SLE: Administer the first subcutaneous dose 1 to 4 weeks after the last intravenous dose. IV and SC are not to be used concurrently.
Patients with LN: Transition to subcutaneous therapy can be done any time after the patient completes the first 2 intravenous doses. Administer the first subcutaneous dose 1 to 2 weeks after the last intravenous dose. IV and SC are not to be used concurrently.
Did you know?

76% of patients with SLE taking BENLYSTA preferred administration with the Autoinjector over IV infusion*
* A follow-up survey was conducted in patients with SLE (N=43) who completed open-label, multi-dose, usability, tolerability, and safety study of subcutaneous (SC) belimumab where they were switched from IV or prefilled syringe belimumab to self-administered doses using the Autoinjector for 8 weekly doses. Patients (n=42) were asked, “What is your preference for receiving BENLYSTA: using the Autoinjector or IV?”
BENLYSTA IV
10 mg/kg intravenous infusion (in-office)
Scheduling first 3 doses in advance may be helpful for patients
BENLYSTA IV is administered as a 1-hour infusion
10 mg/kg administered every 2 weeks for the first 3 doses and every 4 weeks thereafter
BENLYSTA IV is supplied as:
120 mg in a 5-mL single-dose vial
400 mg in a 20-mL single-dose vial
Dosing schedule for SLE and LN
Consider scheduling the first 3 doses in advance to start your patients off right.

BENLYSTA PREFILLED GLASS SYRINGE FOR SC USE
Instructions for use (at home):
200 mg/mL single-dose prefilled glass syringe
BENLYSTA Prefilled Syringe SC dosing for SLE

BENLYSTA Prefilled Syringe SC dosing for active lupus nephritis

* The 400-mg dose requires administration of 2 prefilled syringes (2 x 200 mg). The dose is given via subcutaneous injection in the abdomen or thigh. When the 400-mg dose is administered at the same site, it is recommended that the 2 individual 200-mg injections be administered at least 5 cm (approximately 2 inches) apart.